DOXIFLO-D ™

DOXIFLO TAB 400 MG TABLET
Generic : Doxophyline
Thearapeutic : Respiratory
Pack Size : 50s
Strength :
Dosage Form : Tablet

Doxiflo

Doxophylline

Composition

  • Doxiflo 200 mg Tablet: Each film-coated tablet contains Doxophylline INN 200 mg.
  • Doxiflo 400 mg Tablet: Each film-coated tablet contains Doxophylline INN 400 mg.

Pharmacology

Doxophylline is a new generation xanthine derivative which has a dioxolane group at N-7 position of its chemical structure. Doxophylline inhibits phosphodiesterase activities. Moreover, Doxophylline appears to have a less affinity towards adenosine A1 and A2 receptors which is account for the better safety profile of the drug. Doxophylline also inhibits platelet activating factor and the generation of leukotrienes.

Indications

  • Doxiflo (Doxophylline) is used to treat Asthma, COPD and Bronchospasm.

Dosage and Administration

Adult: 400 mg (1 tablet) daily in the evening. However, in certain cases, 400 mg twice daily is recommended on the basis of the clinical response. Doses as high as 1200 mg/day (400 mg 3 times daily) may also be prescribed. In elderly patients with concomitant cardiovascular, hepatic and renal diseases recommended dosage should be 200 mg twice daily.

Children (above 6 years of age): The recommended dosage of Doxophylline is 6 mg/kg twice daily. The dose may be increased up to 18 mg/kg daily on the basis of clinical response.

Side-Effect

  • After administration, occasionally nausea, vomiting, and headache may occur.

Contraindications

Doxophylline is contraindicated in individuals who have shown hypersensitivity to its components. It is also contraindicated in patients with acute myocardial infarction and hypotension.

Precautions

The half-life of the xanthine derivative is influenced by a number of variables. It may be prolonged in patients with liver disease, congestive heart failure and in those patients taking certain other drugs (erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propranolol, and anit-flu vaccine). a lower dose of Doxophylline may be needed, Phenytoin and other anticonvulsants may cause shorter mean half-life and in these cases, higher doses of Doxophylline may be needed.

Use in pregnancy

Animal reproduction studies indicate that Doxophylline does not cause fetal harm when administered to pregnant animals nor can affect reproduction capacity. However, since there is limited experience in humans during pregnancy, Doxophylline should be given to pregnant women only if clearly needed.

Use in nursing mothers: Doxophylline is contraindicated in nursing mothers.

Drug interactions

Doxophylline should not be administered together with other xanthine derivatives. Toxic synergism with ephedrine has been documented for xanthines, like other xanthines, concomitant therapy with erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, ranitidine, propranolol, and anit-flu vaccine may decrease the hepatic clearance of xanthines causing an increase in blood levels.

Storage

  • Store in a dry place below 30, Keep away from light, and Keep out of reach of the children.

Commercial Pack

  • Doxiflo 200 mg Tablet: Each box contains 50 tablets in an alu-alu blister pack.
  • Doxiflo 400 mg Tablet: Each box contains 50 tablets in the alu-alu blister pack.
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