Clof

Aceclofenac

COMPOSITION

• Clof 100 mg Tablet: Each film-coated tablet contains Aceclofenac BP 100 mg.

PHARMACOLOGY

Clof(Aceclofenac) is a non-steroidal agent with marked anti-inflammatory and analgesic properties. It is a potent inhibitor of the enzyme cyclooxygenase, which is involved in the production of prostaglandin. After oral administration, Aceclofenac is rapidly and completely absorbed as an unchanged drug. Peak plasma concentrations are reached approximately

INDICATION

• For the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis
• and ankylosing spondylitis.

DOSAGE AND ADMINISTRATION

• Adults: The recommended dose is 100 mg, twice daily. Children: There are no clinical data on the use of Aceclofenac in children.
• Elderly: The pharmacokinetics of Aceclofenac is not altered in elderly patients, therefore it is not considered necessary to modify the dose or dose frequency.

CONTRAINDICATION AND PRECAUTION

Aceclofenac should not be administered to patients with active or suspected peptic ulcer or gastric-intestinal bleeding. It should not be given to patients with moderate to severe renal impairment. Close medical surveillance is also imperative in patients suffering from severe impairment of hepatic function. It should not be prescribed during pregnancy unless there are compelling reasons for doing so. The lowest effective dosage should be used.

SIDE EFFECT

The majority of side effects observed have been reversible and of a minor nature and include gastrointestinal disorders (dyspepsia, abdominal pain, nausea, and diarrhea) and the occasional occurrence of dizziness. Dermatological complaints including pruritus and rash abnormal hepatic enzyme levels and raised serum creatinine have occasionally been reported.

USE IN PREGNANCY AND LACTATION

There is no information on the use of Aceclofenac during pregnancy. The regular use of NSAIDs during the last trimester of pregnancy may increase uterine tone and contraction. There is no information on the secretion of Aceclofenac to breast milk. The use of Aceclofenac should therefore be avoided in pregnancy and lactation unless the potential benefits to the mother outweigh the possible risks to the fetus.

STORAGE CONDITION

• Keep at a cool and dry place, protected from light and moisture.

COMMERCIAL PACK

• Clof 100 mg Tablet: Each box contains 10 x 10 tablets in an Alu-PVC blister pack.

Biopharma Ltd. produces CLOF 100 MG TABLET It is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.