Cipcin
Ciprofloxacin 0.3%
Sterile and Pyrogen Eye/Ear Drops
Composition
Each ml contains Ciprofloxacin Hydrochloride BP equivalent to Ciprofloxacin 3 mg. Preservative: Benzalkonium Chloride BP 0.06 mg
Clinical Pharmacology
Ciprofloxacin has in vitro activity against a wide range of Gram-negative and Gram-positive organisms.
Ciprofloxacin is bactericidal and acts by inhibiting the A subunits of DNA gyrase (topoisomerase) which is essential in the reproduction of bacterial DNA.
Indications and Uses
Ciprofloxacin 0.3% ophthalmic solution is indicated for the treatment of corneal ulcers, conjunctivitis, and blepharitis, which are caused by susceptible strains of bacteria.
Dosage and Administration
For Corneal Ulcers:
Instill 2 drops into the affected eye every 15 minutes for the first six hours and then 2 drops into the affected eye every 30 minutes for the remainder of the first day. On the second day, instill 2 drops into the affected eye hourly. On the third through the fourteenth day, place 2 drops into the affected eye every four hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occurred.
Bacterial Conjunctivitis/Blepharitis:
Instill 1 drop to the conjunctival sac(s) every two hours for two days and 1 drop every four hours for the next five days.
Contraindications
A history of hypersensitivity to Ciprofloxacin or any other component of the product. A history of hypersensitivity to other quinolones, including Nalidixic acid, may also contraindicate the use of Ciprofloxacin.
Precautions
General: As with other anti-infective, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If super-infection occurs, discontinue use and initiate alternative therapy. Ciprofloxacin should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity reaction.
Use in Pregnancy & Lactation
There are no adequate and well-controlled studies in pregnant women. Ciprofloxacin ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Drug Interactions
Specific drug interaction studies have not been conducted with ophthalmic Ciprofloxacin. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant warfarin and its derivatives, and have been associated with transient elevations in serum creatinine in patients receiving cyclosporin concomitantly.
Overdosage
A topical overdose of Ciprofloxacin eye drops may be flushed from the eye(s) with warm tap water.
Pharmaceutical Precautions
Store at room temperature, and protect from light. It is desirable that the contents should not be used more than one month after the first opening of the bottle.
Commercial Pack
Plastic dropper bottle of 5 ml.
Biopharma Ltd. produces CIPCIN 5 ML EYE DROPS, It is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.
