XDERM-N ™

XDERM N CREAM
Generic : Clobetasol Propionate + Neomycin Sulphate + Nystatin
Thearapeutic : Topical Corticosteroid
Pack Size : 10 gm
Strength :
Dosage Form : Cream

Xderm-N

Clobetasol Propionate BP, Neomycin Sulphate BP and Nystatin USP

COMPOSITION

  • Xderm-N Cream 10 gm: Each gram of Xderm-N cream contains Clobetasol Propionate BP 0.5 mg, Neomycin Sulphate BP 5 mg and Nystatin USP 100,000 units.
  • Xderm-N Ointment 15 gm: Each gram of Xderm-N ointment contains Clobetasol Propionate BP 0.5 mg, Neomycin Sulphate BP 5 mg and Nystatin USP 100,000 units.

PHARMACOLOGY

Xderm-N contains three active ingredients- Clobetasol Propionate, Neomycin Sulphate, and Nystatin. Clobetasol Propionate is a very potent corticosteroid. It is prescribed to treat severe inflammatory skin disorders such as eczema and psoriasis that have not responded to weaker corticosteroids. Neomycin Sulphate is an antibiotic of the aminoglycoside type and is used to treat infections with bacteria. Nystatin is an antifungal that kills fungi and yeasts by interfering with their cell membranes.

INDICATION

Xderm-N is indicated in courses of treatment of recalcitrant eczemas Neurodermatoses Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial infection or fungal infection is present, suspected or likely to occur. Other inflammatory conditions which do not respond satisfactorily to less active steroids.

DOSAGE AND ADMINISTRATION

Adults: Apply sparingly to the affected area once or twice daily until improvement occurs. In very resistant lesions, especially where there is hyperkeratosis, the anti-inflammatory effect of Xderm-N can be enhanced (if necessary) by occluding the treatment area with polythene. Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient's condition being reviewed. Elderly: Xderm-N is suitable for use in the elderly. Caution should be exercised in cases where a decrease in renal function exists and significant systemic absorption of Neomycin Sulphate may occur. Children: Xderm-N is suitable for use in children (2 years and over) at the same dose as adults. A possibility of increased absorption exists in very young children, thus Xderm-N is not recommended for use in neonates and infants (younger than 2 years).

CONTRAINDICATION

  • This medication is contraindicated in rosacea, acne vulgaris and perioral dermatitis, primary cutaneous viral infection (eg-Herpes simplex, chicken pox) and hypersensitivity to the preparation.

PRECAUTION

Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye, as glaucoma might result. If this medication does enter the eye, the affected eye should be thoroughly washed with copious amounts of water.

USE IN PREGNANCY AND LACTATION

There is little information to demonstrate the possible effect of topically applied Neomycin in pregnancy and lactation. However, Neomycin present in the maternal blood can cross the placenta and may give rise to a theoretical risk of foetal toxicity, thus the use of the preparation is not recommended in pregnancy and lactation. The safety of Clobetasol Propionate has not been established in lactating mothers.

ADVERSE EFFECT

As with other topical corticosteroids, prolonged use of large amounts or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism. The effect is more likely to occur in infants and children and if occlusive dressings are used. Prolonged and intensive treatment with highly active corticosteroid preparations may cause local atrophic changes in the skin such as thinning, striae, and dilation of the superficial blood vessels, particularly when occlusive dressings are used, or when skin folds are involved. There are reports of pigmentation changes and hypertrichosis with topical steroids.

DRUG INTERACTION

Neomycin Sulphate can intensify and prolong the respiratory depressant effects of neuromuscular blocking agents following significant systemic absorption. However, if used in accordance with the recommendations, systemic exposure to Neomycin Sulphate is expected to be minimal and drug interactions are unlikely to be significant. No hazardous interactions have been reported with the use of Clobetasol Propionate or Nystatin.

OVERDOSAGE

  • Acute overdosage is very unlikely to occur. No overdose-related problem has yet been reported. However, in the case of chronic overdosage or misuse the features of hypercortisolism may appear and in this situation, topical steroids should be discontinued gradually.

STORAGE CONDITION

  • Store below 25o C temperature. Do not freeze. Keep out of reach of children.

COMMERCIAL PACK

  • Xderm-N Cream 10 gm: Each pack has an aluminium tube containing 10 gm of cream.
  • Xderm-N Ointment 15 gm: Each pack has an aluminium collapsible tube containing 15 gm ointment.

Biopharma Ltd. Produces XDERM N CREAM it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.

BIOPHARMA   AFFILIATE  COMPANIES