Urospin

Spironolactone + Furosemide

Composition

• Each film-coated tablet contains Spironolactone USP 50 mg and Furosemide USP 20 mg.

Description

Urospin is a combination of diuretics containing a loop diuretic, Furosemide and potassium sparing diuretics, spironolactone. Spironolactone and Furosemide have different but complementary mechanisms and sites of action. Therefore, when given together they produce additive or synergistic diuretic effects. Furosemide inhibits the Na+/K+/Cl- co-transporter in the ascending Loop of Henle and blocks the reabsorption of sodium, potassium, and chloride ions thereby increasing the quantity of sodium and the volume of water excreted in the urine. This induces potassium loss. Spironolactone inhibits the reabsorption of sodium in exchange for potassium at the distal tubule by antagonizing the action of aldosterone so that sodium excretion is greatly favored and the excess loss of potassium induced by the Furosemide is reduced.

Indication

Urospin is indicated in the treatment of the following diseases:

1. Essential Hypertension

2. Chronic congestive heart failure

3. Hepatic cirrhosis with collection of fluid in the abdominal cavity

4. Swelling due to excess fluid retention (edema)

5.  Hyperaldosteronism

6.   Resistant edema associated with secondary hyperaldosteronism.

Dosage and Administration

Adult: 1 to 4 tablets daily (50 to 200 mg of spironolactone and 20 to 80 mg of Furosemide) according to the patient’s response or as directed by a physician.

Children: Not recommended

Side effects

Spironolactone may give rise to headaches and drowsiness, gastrointestinal distress, including cramps and diarrhea. Ataxia, mental confusion, and skin rashes have also been reported.

Contra-indication

Patients with an impaired renal function and a creatinine clearance below 30ml/min per 1.73 m2 body surface area, anuria or renal failure with anuria not responding to Furosemide, renal failure as a result of poisoning by nephrotoxic or hepatotoxic agents or renal failure associated with hepatic coma, hyperkalemia, severe hypokalaemia, severe hyponatremia, Addison's disease, and breastfeeding women.

Hypersensitivity to Furosemide, Spironolactone, Sulphonamides Sulphonamide derivatives, or any of the excipients of Urospin.

Precaution

Cautions should be taken in patients with electrolyte deficiency. This preparation should also be used with caution in diabetes, enlarged prostate, hypotension, and hypovolemia.

Warning

• Prescription-only medicine. To be used as directed by the physician. Keep out of reach of children.

Drug interaction

When taken together with ACE inhibitors or potassium salts there is an increased risk of hyperkalemia, Spironolactone increases the level of cardiac glycoside such as digoxin in the blood and this may result in digitalis toxicity. Corticosteroids may cause hypokalemia when used with Spironolactone.

Use in pregnancy and lactation

Spironolactone and its metabolites may cross the placental barrier. The use of spironolactone in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the mother and fetus. Metabolites of spironolactone have been detected in breast milk. If the use of spironolactone is considered essential, an alternative method of infant feeding should be instituted. Furosemide is excreted in breast milk and breastfeeding should be discontinued if treatment is essential.

Storage condition

• Store at temperatures not exceeding 30ºC in a dry place. Keep away from light.

Commercial Pack

• Each box contains 3x10 tablets in a blister pack.

Biopharma Ltd. Produces UROSPIN 20 MG TABLET it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.