Trangina MR
Trimetazidine Hydrochloride 35 mg
Modified Release Tablet
Composition
Trangina MR tablet: Each modified release tablet contains Trimetazidine Hydrochloride BP 35 mg.
Description
- Mechanism of Action: Trimetazidine Hydrochloride has been proven to exert antianginal properties due to its specific metabolic mechanism of action. Indeed, Trimetazidine
- Hydrochloride reduces the metabolic damage caused during ischemia, by acting on a critical step in cardiac metabolism: fatty acid β-oxidation. This is made possible by selective inhibition of an enzyme of fatty acid β-oxidation: the long-chain 3-ketoacyl CoA thiolase (3-KAT). This inhibition results in a reduction in fatty acid oxidation & stimulation of glucose oxidation.
- Thus, the coupling of glycolysis with glucose oxidation is improved, and ATP production
- is further increased, while the deleterious consequences of acidosis and Ca2+ overload are limited.
- Under ischemic conditions, Trimetazidine Hydrochloride optimizes cardiac metabolism through a metabolic switch from fatty acid oxidation to glucose oxidation. This supports the anti-ischemic benefits of Trimetazidine Hydrochloride.
Indications and uses
- Long-term treatment of angina pectoris.
- Dosage & Administration
- 1 tablet at mealtimes in the morning and evening.
Contraindications
Severe depression, and severe renal failure (creatinine clearance <15 ml/min), as a precaution in the absence of currently available studies.
Side effects
- Rare cases of gastrointestinal disorders.
- Use in pregnancy and lactation
- Pregnancy: Studies in animals have not demonstrated a teratogenic effect. However, in
- the absence of clinical data and for safety reasons, prescription should be avoided during pregnancy.
- Breastfeeding: In the absence of data, breastfeeding is not recommended during treatment.
Storage Condition
Store in a cool and dry place, protect from light and moisture. Keep out of the reach of children.
Commercial Pack
Trangina MR tablet: Each box contains 3x10 tablets in an alu-alu blister pack
Biopharma Ltd. Produces a TRANGINA MR TABLET it is a trusted product for alleviating various discomforts, commonly found in pharmacies and stores.
