Avert Plus

Meclizine Hydrochloride BP 25 mg &

Pyridoxine Hydrochloride BP 50 mg

Composition:

• Avert Plus Tablet: Each film-coated tablet contains Meclizine Hydrochloride BP 25 mg and pyridoxine Hydrochloride BP 50 mg.

Description:

Avert Plus is a combination of Meclizine Hydrochloride and Pyridoxine Hydrochloride. Meclizine has antiemetic, anticholinergic, and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Pyridoxine Hydrochloride (Vit - B6), either alone or in combination has been used to prevent nausea & vomiting due to its antiemetic properties.

Indications:

For prophylaxis and symptomatic relief of nausea, vomiting, dizziness, motion sickness, radiation sickness, and vertigo associated with diseases of vestibular motion sickness, radiation sickness, and vertigo associated with diseases of the vestibular system, morning sickness during pregnancy, drug-induced nausea, vomiting induced by oral contraceptives or Estrogen preparations.

Dosage and Administration:

The fixed-dose combination (FDC) is recommended for oral administration. Nausea & vomiting (including morning sickness in pregnancy): One tablet 1-2 times daily or as directed by a physician. Motion sickness: One or two tablets one hour prior to the journey. The dose may be repeated every 24 hours as indicated for the duration of the journey. Vertigo: One tablet 2 times daily or as directed by a physician. Labyrinthine and vestibular disturbances: The optimal dose of Meclizine Hydrochloride is usually 25 to 100 mg daily in divided doses, depending on the clinical response. Radiation sickness: 50 mg (Meclizine Hydrochloride) administered 2 to 12 hours prior to radiation treatment. Pyridoxine Hydrochloride (vitamin B6) has been shown to be safe and effective in dosages of 50 to 200 mg per day.

Contra-indications:

• Avert Plus is contra-indicated in individuals who have shown hypersensitivity to these ingredients.

Side-Effects:

• Drowsiness, dry mouth, urinary retention on rare occasions, and blurred vision have been reported. Sensory neuropathy was reported with a high dosage of Pyridoxine Hydrochloride given for extended periods.

Precautions:

• Due to its potential anticholinergic action, patients with asthma, bronchitis, emphysema, enlarged prostate, glaucoma, or urinary tract blockade should take meclizine HCl (like other antiemetics) with caution.

High Risk Groups:

Pregnancy: Meclizine Hydrochloride is a pregnancy Category B drug. Large-scale human studies have not demonstrated adverse fetal effects. It has been suggested that, based on available data, Meclizine Hydrochloride presents the lowest risk of teratogenicity and is the drug of first choice in treating nausea and vomiting during pregnancy. On the other hand, Pyridoxine Hydrochloride is a pregnancy category A drug. Pyridoxine Hydrochloride itself is considered safe during pregnancy and has been used in pregnant women without any evidence of fetal harm.

Lactation:

• Meclizine Hydrochloride may be distributed into breast milk. However, problems in humans have not been documented. On the other hand, Pyridoxine Hydrochloride has no adverse effects during lactation.

Children:

• Safety and efficacy have not been established below 2 years of children.

Drug Interactions:

There may be increased CNS depression when Meclizine Hydrochloride and Pyridoxine Hydrochloride are administered concurrently with other CNS depressants, including benzodiazepines, barbiturates, tricyclic antidepressants, opiate agonists, skeletal muscle relaxants, antihistamines, alcohol, tranquilizers. Meclizine Hydrochloride can increase the absorption of digoxin by decreasing gastrointestinal motility. MAO inhibitors may prolong and intensify the anticholinergic effects of meclizine Hydrochloride.

Over Dosage:

• Symptoms: Moderate overdose may cause hyperexcitability alternating with drowsiness. Massive overdosage may cause convulsions, hallucinations, and respiratory paralysis.

Storage:

• Store in a cool and dry place, and protect from light. Keep out of reach of the children.

Commercial Pack:

• Avert Plus Tablet: Each box contains a 5x10 tablet in a blister pack.

Biopharma Ltd. produces AMOTID CL PFS, It is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.