AVERT ™
AVERT 50 MG TABLET | |
---|---|
Generic : | Meclizine Hydrochloride |
Thearapeutic : | Antiemetic |
Pack Size : | 50s |
Strength : | |
Dosage Form : | Tablet |
Avert
Meclizine Hydrochloride BP 50 mg
Composition
- Avert 50 mg Tablet: Each film-coated tablet contains Meclizine Hydrochloride BP 50 mg.
Description
Avert is a Meclizine Hydrochloride. Meclizine has antiemetics, anticholinergic, and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers.
Indications
- For prophylaxis and symptomatic relief of nausea, vomiting, dizziness, motion sickness, radiation sickness, and vertigo associated with diseases of vestibular motion sickness, radiation sickness, and vertigo associated with diseases of the vestibular system, morning sickness during pregnancy, drug-induced nausea,
- vomiting induced by oral contraceptives or Estrogen preparations.
Dosage and Administration
- The fixed-dose combination (FDC) is recommended for oral administration.
- Nausea & vomiting (including morning sickness in pregnancy): One tablet 1-2 times daily or as directed by a physician.
Motion sickness:
- One or two tablets one hour prior to the journey. The dose may be repeated every 24 hours as indicated for the duration of the journey.
Vertigo:
- One tablet 2 times daily or as directed by a physician.
- Labyrinthine and vestibular disturbances: The optimal dose of Meclizine Hydrochloride is usually 25 to 100 mg daily in divided doses, depending on the clinical response.
- Radiation sickness: 50 mg (Meclizine Hydrochloride) administered 2 to 12 hours prior to radiation treatment.
Contra-indications
- Avert is contra-indicated in individuals who have shown hypersensitivity to these ingredients.
Side-Effects
- Drowsiness, dry mouth, urinary retention on rare occasions, and blurred vision have been reported. Sensory neuropathy was reported with a high dosage of Pyridoxine Hydrochloride given for extended periods.
Precautions
Due to its potential anticholinergic action, patients with asthma, bronchitis, emphysema, enlarged prostate, glaucoma, or urinary tract blockade should take meclizine HCI (like other antiemetics) with caution.
High Risk Groups
Pregnancy: Meclizine Hydrochloride is a pregnancy Category B drug. Large-scale human studies have not demonstrated adverse fetal effects. It has been suggested that, based on available data, Meclizine Hydrochloride presents the lowest risk of
teratogenicity and is the drug of first choice in treating nausea and vomiting during pregnancy.
Lactation:
- Meclizine Hydrochloride may be distributed into breast milk. However, problems in humans have not been documented.
Children:
- Safety and efficacy have not been established below 2 years of children.
Drug Interactions
There may be increased CNS depression when Meclizine Hydrochloride is administered concurrently with other CNS depressants, including benzodiazepines, barbiturates, tricyclic antidepressants, oplate agonists, skeletal muscle relaxants, antihistamines, alcohol, and tranquilizers. Meclizine Hydrochloride can increase the absorption of digoxin by decreasing gastrointestinal motility. MAO inhibitors may prolong and intensify the anticholinergic effects of Meclizine Hydrochloride.
Over Dosage
- Symptoms: Moderate overdose may cause hyperexcitability alternating with drowsiness. Massive overdosage may cause convulsions, hallucinations, and respiratory paralysis.
Storage
- Store in a cool and dry place, and protect from light. Keep out of reach of the children.
Commercial pack
- Avert 50 mg Tablet: Each box contains 5x10 tablets in a blister pack.
Biopharma Ltd. produces AVERT 50 MG TABLET, It is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.