Pimplex Cream 0.1%

Adapalene BP

COMPOSITION

• Pimplex 10gm Cream: Each gram Pimplex cream contain Adapalene BP 1 mg.

PHARMACOLOGY

Adapalene acts on retinoid receptors that are commonly found in the skin of face, back and chest. Biochemical and pharmacological studies have demonstrated that Adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of that represent important features in the pathology of acne vulgaris. Adapalene binds with specific retinoic acid nuclear receptors that normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Absorption of Adapalene through human skin is low.

INDICATION

• Pimplex Cream 0.1% are indicated for topical treatment of acne vulgaris.

DOSAGE AND ADMINISTRATION

• Pimplex Cream 0.1%: Should be applied to the affected areas of skin, once daily at night-time A thin film of gel or cream should be applied to the skin areas where lesions present, using enough to cover the entire affected areas lightly For detail information, please see the enclosed leaflet

PRECAUTION

• Adapalene should not be applied to cuts, abrasions, eczematous or sunburned skin.

SIDE EFFECT

• Erythema, scaling, dryness, pruritus, burning sensation, skin irritation, stinging sunburn, acne flares, etc. are commonly seen during the first month of therapy but usually lessen with continued use of the medication.

DRUG INTERACTION

Concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime) should be approached with caution Exercise particular caution in using preparations containing sulfur, resorcinol or salicylic acid in combination with Adapalene If any of these preparations have been used, it is advisable not to start therapy with Adapalene until the effects of such preparations in skin have subsided. If combined use of both medications is important, it is better to use in two different times.

USE IN PREGNANCY AND LACTATION

• Use Adapalene during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in breast milk. Exercise caution when administering Adapalene to a nursing mother.

USE IN CHILDREN

• Safety and effectiveness in children below 12 years of age have not been established.

STORAGE

• Store in a cool and dry place (below 250C). Do not freeze.

COMMERCIAL PACK

• Pimplex 10 gm Cream: Each pack has a Aluminium colapsible tube containing 10 gm cream.

Biopharma Ltd. Produces PIMPLEX CREAM 10 GM it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.