ORTHORATE ™
ORTHORATE 400 TABLET | |
---|---|
Generic : | Calcium Orotate |
Thearapeutic : | Vitamin & Minerals |
Pack Size : | 30s |
Strength : | |
Dosage Form : | Tablet |
Orthorate 400
Calcium Orotate
COMPOSITION
- Orthorate 400 mg tablet: Each film coated tablet contains Calcium Orotate Dihydrate INN equivalent to Calcium Orotate 400 mg.
PHARMACOLOGY
- Adequate Calcium in the blood is so vital to a wide variety of bodily functions that human body will not tolerate a deficiency even for short periods. Clinical evidence suggests that Calcium is useful for the prevention and treatment of Osteoporosis and associated fractures.
PHARMACOKINETICS
Orthorate contains Calcium Orotate, a Calcium supplement with a functional amino acid chelating ligand-Orotic acid. Orotic acid assists the transport of Calcium through cellular membrane structures facilitating the intracellular uptake of Calcium, particularly in bone. Calcium Orotate also helps in the maintenance of healthy cartilage. Furthermore, Orotate is involved in the synthesis of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). Calcium Orotate has the high affinity to penetrate complex cell membrane.
INDICATIONS
1. To prevent or to treat low blood Calcium levels
2. To treat conditions caused by low Calcium levels i.e. bone loss :
n Osteoporosis
n Postmenopausal Osteoporosis
n Juvenile Osteoporosis
n Senile Osteoporosis
n Osteomalacia
n Rickets
3. Hypoparathyroidism
4. Latent tetany
5. Hip joint plastic surgery
6. Many inflammatory diseases like: Arthritis, Spondylitis etc.
7. Pregnant women & nursing mothers
8. Premenstrual syndrome (PMS)
9. Helps in controlling weight by suppressing the habit of frequent appetite
10. Mood swings
11. Cognitive enhancement
12. Protects the heart by enhancing the efficiency of cardiac muscles
DOSAGE AND ADMINISTRATION
- Orthorate 400 : As an addition to the daily diet, 2-3 tablets are usually recommended with meal, after meal or as directed by physician.
CONTRAINDICATIONS
- Calcium Orotate is contraindicated in conditions like kidney stone, kidney disease, increased activity of the parathyroid gland, high amount of Calcium in urine & blood and extreme loss of body water.
SIDE EFFECTS
- Bloating and swelling in the abdomen are common side effects of Calcium Orotate. Loss of appetite, constipation, nausea, vomiting, unusual weight loss, headache and increased thirst/urination. Formation of kidney stones may occur infrequently.
PRECAUTIONS
- Precaution is needed if the patient is allergic to Calcium Orotate. Before using this product in kidney disease, kidney stones, little or no stomach acid (achlorhydria), disease of the pancreas, a certain lung disease (sarcoidosis), difficulty absorbing nutrition from food precaution is needed.
DRUG INTERACTIONS
Calcium can decrease absorption of the following drugs when taken together with bisphosphonates, quinolone antibiotics, tetracycline antibiotics, levothyroxine, phenytoin and tiludronate disodium. Thiazide-type diuretics can interact with Calcium supplements, increasing the risks of hypercalcemia and hypercalciuria.
USE IN PREGNANCY AND LACTATION
During pregnancy and lactation treatment with Orthorate should always be under the direction of a physician. Women who are pregnant and breast-feeding need more Calcium. Pregnancy related high blood pressure is a common and serious risk for women and their babies. Taking supplement of Calcium Orotate can help to reduce this risk.
OVERDOSE
- Symptoms of over dose may include nausea/vomiting, weightloss, loss of appetite, constipation, headache, weakness etc if any of the side effects become serious please talk with physician.
STORAGE
- Store below 30º C. Protect from light and moisture. Keep out of the reach of children.
COMMERCIAL PACK
- Orthorate 400 : Each box contains 30 tablets in Alu-PVC pack.
Biopharma Ltd. Produces ORTHORATE 400 TABLET it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.