ASCLOP ™
ASCLOP TABLET | |
---|---|
Generic : | Aspirin + Clopidogrel |
Thearapeutic : | Cardiovascular Drug |
Pack Size : | 30s |
Strength : | |
Dosage Form : | Tablet |
Asclop
Aspirin 75 mg & Clopidogrel 75 mg
Presentation
Asclop tablet: Each film-coated tablet contains Aspirin USP 75mg and Clopidogrel Bisulfate USP equivalent to Clopidogrel 75 mg.
Description
Asclop is a fixed-dose combination containing Clopidogrel and Aspirin. Clopidogrel is an inhibitor of platelet aggregation. Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.
Aspirin is also an antiplatelet agent. It acts by causing irreversible inhibition of the cyclo-oxygenase enzyme, which leads to decreased formation of thromboxane A2. Since platelets do not synthesize new enzymes, the action of Aspirin on platelet cyclo-oxygenase is permanent, lasting for the life of the platelets (7-10 days).
Indications
Asclop is indicated for the prevention of ischemic events, myocardial infarction, stroke, and cardiovascular death in patients with acute coronary syndrome.
Dosage and Administration
The recommended dose is one tablet once daily.
Contraindications
- · Hypersensitivity to Clopidogrel
- · Hypersensitivity to Aspirin and/or non-steroidal anti-inflammatory drugs
- · Recent history of gastrointestinal bleeding
- · Active pathological bleeding such as a peptic ulcer or intracranial hemorrhage, or bleeding disorders like hemophilia.
Precautions
General: Like other anti-platelet agents, Clopidogrel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. If a patient is to undergo elective surgery and an antiplatelet effect is not desired, Clopidogrel should be discontinued 7 days prior to surgery.
Therapeutic Index
Hepatic or renal impairment: Should be avoided in patients with impaired hepatic and renal function. Aspirin causes sodium and water retention in patients with renal impairment and increases the risk of gastrointestinal bleeding.
Drug Interactions
The safety of chronic concomitant administration of Aspirin, Heparin, Nonsteroidal anti-inflammatory drugs (NSAIDs), Warfarin, Phenytoin, Tamoxifen, Tolbutamide, Warfarin, Torsemide, Fluvastatin with Clopidogrel has not been established. However, concomitant use should be undertaken with caution.
Side Effects
The drug is generally well tolerated. Adverse effects that have been reported about Clopidogrel are gastrointestinal disturbances and skin rashes. Neutropenia and thrombotic thrombocytopenic purpura have also occurred. The most common adverse effects of therapeutic doses of aspirin are nausea, dyspepsia, and vomiting. Irritation of the gastric mucosa with erosion, and ulceration may occur.
Use in Special Populations
Pregnancy: Adverse effects are increased in the mother and the fetus following chronic ingestion of Aspirin. Because of possible adverse effects on the neonate and the potential for increased maternal blood loss. Asclop should be avoided during the last trimester of pregnancy. Lactation: Asclop should be avoided in nursing mothers because of the possible risk of developing Reye’s syndrome. Regular use of high doses of Aspirin could impair platelet function and produce hypoprothrombinaemia in infants if neonatal vitamin K levels are low. Pediatric use: The safety and efficacy of Asclop in the pediatric population have not been established.
Commercial Pack
- Asclop Tablet: Each box contains 3 Alu-Alu blister packs of 10 tablets.
Biopharma Ltd. produces ASCLOP TABLET, It is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.