OLVANCE-AM ™

OLVANCE-AM TABLET
Generic : Olmesartan 20mg + Amlodipine 5mg
Thearapeutic : Cardiovascular Drug
Pack Size : 30s
Strength :
Dosage Form : Tablet

OLVANCE-AM 

Olvance AM

Olmesartan Medoxomil BP 20 mg

COMPOSITION

  • Olvance AM 20/5 mg Tablet: Each film-coated tablet contains Olmesartan Medoxomil BP 20 mg and Amlodipine Besilate BP equivalent to Amlodipine 5 mg.

PHARMACOLOGY

This product is a combination of two antihypertensive drugs: Olmesartan medoxomil is an Angiotensin-II receptor blocker and Amlodipine is a dihydropyridine calcium antagonist. The Olmesartan Medoxomil component blocks the vasoconstrictor effects of angiotensin-II and The Amlodipine component inhibits the transmembrane influx of calcium ions into vascular smooth muscle.

INDICATION

Olvance AM is indicated for the treatment of hypertension, alone or with other antihypertensive agents. Olvance AM may also be taken as initial therapy in patients who are likely to need multiple antihypertensive agents to achieve their blood pressure goals.

DOSAGE & ADMINISTRATION

  • Initial Therapy
  • The usual recommended dosage of Olvance AM is one tablet once daily.
  • Olvance AM 20/5 tablet may be administered in patients whose blood pressure is not adequately controlled by 20 mg Olmesartan Medoxomil or 5 mg Amlodipine alone.
  • The dosage can be increased after 1 to 2 weeks of therapy to a maximum dose of 40/10 mg once daily as needed to control blood pressure. Olvance AM may be taken with or without food. Olvance AM may be administered with other antihypertensive agents. Initial therapy with this combination product is not recommended in patients >75 years old or with hepatic impairment.

Replacement Therapy

  • Olvance AM may be substituted for its individually titrated components. When substituting for individual components, the dose of one or both of the components can be increased if blood pressure control has not been satisfactory.

Route of Administration

  • Oral route only.

CONTRAINDICATION

  • Aliskiren is contraindicated with Olvance AM in patients with diabetes.

PRECAUTION AND WARNING

When pregnancy is detected, this combination drug should be discontinued as soon as possible. Symptomatic hypotension may occur after initiation of therapy. Olvance AM should be used with caution in patients with congestive heart failure, impaired renal function / hepatic impairment, patients with severe aortic stenosis, and severe obstructive coronary artery disease. Patients may develop increased frequency, duration or severity of angina or acute MI or start Calcium Channel Blocker therapy at the time of dosage increase. As with other angiotensin receptor antagonists and ACE inhibitors, hyperkalaemia may occur during treatment with Olmesartan medoxomil, especially in the presence of renal impairment and/or heart failure. Olmesartan medoxomil inhibits the renin-angiotensin system (RAS) and drugs that inhibit the RAS can cause hyperkalaemia. Monitor serum electrolytes periodically. Close monitoring of serum potassium levels is recommended.

SIDE EFFECTS

Common

  • The most common side effects include peripheral oedema, dizziness, flushing, vomiting, diarrhoea, rhabdomyolysis, alopecia, pruritus, urticaria etc.

Rare

  • Face oedema, Hypersensivity, syncope, urticaria etc.

USE IN PREGNANCY AND LACTATION

Pregnancy

When pregnancy is detected, discontinue this combination product as soon as possible. When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus.

Nursing Mother

  • Because of the potential for adverse effects on the rising infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

USE IN CHILDREN & ADOLESCENTS

  • Olvance AM is recommended for use in children & adolescents below 18 years of age due to lack of data on safety & efficacy.

DRUG INTERACTION

With medicine

Based on experience with the use of other drugs that affect the renin-angiotensin system, concomitant use of potassium-sparing diuretics, potassium supplements, and salt substitutes containing potassium levels (e.g. heparin) may lead to increases in serum potassium. Such concomitant use is therefore not recommended.

With food & others

  • Administration of amlodipine with grapefruit or grapefruit juice is not recommended as bioavailability may be increased in some patients resulting in increased blood pressure lowering effects.

OVERDOSE

Symptoms

There is no experience of overdose with Olvance AM. The most likely effects of Olmesartan medoxomil overdose are hypotension and tachycardia; bradycardia could be encountered if parasympathetic (vagal) stimulation occurred. Amlodipine overdosage can be expected to lead to excessive peripheral vasodilatation with marked hypotension and possibly reflex tachycardia. Marked and potentially prolonged systemic hypotension up to and including shock with fatal outcome has been reported.

Treatment

If intake is recent, gastric lavage or induction of emesis may be considered. In healthy subjects, the administration of activated charcoal immediately or up to 2 hours after ingestion of amlodipine has been shown to reduce substantially the absorption of amlodipine. Clinically significant hypotension due to an overdose of Olvance AM requires active support of the cardiovascular system, including close monitoring of heart and lung function, elevation of the extremities, and attention to circulating fluid volume and urine output. A vasoconstrictor may be helpful in restoring vascular tone and blood pressure, provided that there is no contraindication to its use. Intravenous calcium gluconate may be beneficial in reversing the effects of calcium channel blockade. Since amlodipine is highly protein-bound, dialysis is not likely to be of benefit. The dialysability of Olmesartan medoxomil is unknown.

STORAGE

  • Store in a cool & dry place below 30, Protect from light & moisture.
  • Keep out of the reach of children.

COMMERCIAL PACK

  • Olvance AM 20/5 mg tablet: Each box contains 3X10 box in an Alu-Alu Blister pack.

Biopharma Ltd. Produces OLVANCE-AM TABLET it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.

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