Amotid

Amoxicillin

REPRESENTATION

• Amotid CL 625 mg Tablet: Each film-coated tablet contains Amoxicillin Trihydrate USP equivalent to Amoxicillin 500 mg and Diluted Potassium Clavulanate BP equivalent to Clavulanic Acid 125 mg.
• Amotid CL Powder for Suspension 100 ml: Each 5 ml reconstituted suspension contains Amoxicillin Trihydrate USP equivalent to Amoxicillin 125 mg and Diluted Potassium Clavulanate BP equivalent to Clavulanic Acid 31.25 mg.

PHARMACOLOGY

Pharmacodynamic properties: Co-Amoxiclav is an antibacterial combination consisting of the antibiotic Amoxicillin and the β-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram-positive & Gram-negative microorganisms but it is susceptible to degradation by β-Iactamases and therefore the spectrum of activity does not include microorganisms, which produce these enzymes. Clavulanic acid possesses the ability to inactivate a wide range of beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. Thus, Clavulanic acid in Amotid CL protects Amoxicillin from degradation by β-Iactamase enzymes and effectively extends the antibiotic spectrum to embrace a wide range of microorganisms.

Pharmacokinetic properties: The pharmacokinetics of the two components of Co-Amoxiclav is closely matched. Peak serum levels of both occur about one hour after oral administration. Absorption of Co-Amoxiclav is optimized at the start of a meal. Both clavulanate and Amoxicillin have low levels of serum binding; about 70% remains free in the serum. Doubling the dosage of Co-Amoxiclav approximately doubles the serum levels achieved.

INDICATION

Amotid CL is indicated for short-term treatment of bacterial infections at the following sites:

1. Upper respiratory tract infections (including ENT) e.g. tonsillitis, sinusitis, otitis media.

2. Lower respiratory tract infections e.g. acute and chronic bronchitis, Iobar, and bronchopneumonia.

3. Genito-urinary tract infections e.g. cystitis, urethritis, pyelonephritis.

4. Skin and soft tissue infections.

5. Bone and joint infections e.g. osteomyelitis.

6. Other infections e.g. septic abortion, puerperal sepsis, intra-abdominal sepsis, etc.

DOSAGE & ADMINISTRATION OF ORAL AMOTID CL PREPARATION

Adults and children over 12 years:

Tablet:

The usual adult dose is one Amotid CL 625mg Tablet every 12 hours. For more severe infections and infections of the respiratory tract, the dose should be one Amotid CL 625 mg Tablet every 8 hours.

Suspension:

• Children 6 - 12 years: 2 teaspoonfuls every 8 hours.
• Children 1 - 6 years: 1 teaspoonful every 8 hours.

Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example, a 7.5 kg child would require 2 ml Amotid CL suspension t.i.d. Treatment should not be extended beyond 14 days without review.

Children of 2 to 12 years:

Mild to moderate infections: 25/3.6 mg/kg/day(Suspension)

• 2-6 years (13-21 kg) 2.5 ml suspension b.i.d
• 7-12 years (22-40 kg) 5 ml suspension b.i.d

Children aged 2 months to 2 years:

Biopharma Ltd. produces AMOTID CL 625 MG TABLET, It is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.