LACTU ™

LACTU 100 ML SOLUTION
Generic : Lactulose
Thearapeutic : Laxative
Pack Size : 100 ml
Strength :
Dosage Form : Solution

Lactu

Lactulose

COMPOSITION

  • Lactu 100ml Oral Solution: Each 5 ml concentrated oral solution contains Lactulose BP 3.35 gm.
  • Lactu 200ml Oral Solution: Each 5 ml concentrated oral solution contains Lactulose BP 3.35 gm.

DESCRIPTION

Lactulose is a disaccharide, which is not hydrolyzed in the small intestine. Therefore it can not be absorbed and is transported to the colon with water to retain the osmotic balance. It provides a natural substrate for the saccharolytic bacterial flora in the colon. In the colon, several species of bacteria can hydrolyze Lactulose to the monosaccharides galactose and fructose. By encouraging this normal metabolic activity of the bacteria, the osmotic pressure of the colonic contents is doubled and more water is drawn into the bowel. Further metabolism of the monosaccharides leads to the production of acetic acids and the subsequent lowering of colonic pH. This acidification of the colonic contents is considered to be the main reason for the effectiveness of the Lactulose solution. In chronic portal systemic encephalopathy it may be associated with a decrease in the relative concentration of free ammonia, the major agent involved in the cerebral disturbance.

INDICATIONS

1. Constipation

2. Hepatic encephalopathy (Portal systemic encephalopathy)

DOSAGE AND ADMINISTRATION

  • Constipation: Initially Lactu solution may be given twice daily. In due course, the dose should be adjusted according to the needs of the individual, but the following serves as a guide

STARTING DOSE

Adults: (including the elderly) - 15 ml twice daily. Children: 5 to 10 years - 10 ml twice daily. Children under 5 years - 5 ml twice daily. Babies under 1 year - 2.5 ml twice daily. Lactu solution may, if necessary, be taken with water, fruit juice, etc. Hepatic encephalopathy: Adults (including the elderly): Initially 30-50 ml three times a day. Subsequently, adjust the dose to produce two or three soft stools each day.

CHILDREN

  • No dosage is recommended for this indication.

CONTRAINDICATION

  • Galactosaemia. In common with other preparations used for the treatment of constipation, Lactulose should not be used when there is evidence of gastrointestinal obstruction.

PRECAUTION

  • Lactose intolerance.

SIDE-EFFECTS

During the first few days of treatment, meteorism and increased flatulence may occur. These symptoms usually disappear under continued therapy. Diarrhea may occur especially when used in higher dosages, e.g. during treatment of portal-systemic encephalopathy. The dosage should then be adjusted to obtain two or three formed stools per day.

USE IN PREGNANCY

Wide clinical experience, together with data from animal reproduction studies has not revealed any increase in embryotoxic hazard to the fetus if used in the recommended dosage during pregnancy. If laxative therapy is needed in pregnancy, use of this drug is acceptable.

STORAGE REQUIREMENT

  • Store below 25oC. Do not freeze. Dilution and subsequent storage are not recommended.

COMMERCIAL PACK

  • Lactu 100 ml: Each amber-colored glass bottle contains Lactu 100 ml oral solution.
  • Lactu 200 ml: Each amber-colored glass bottle contains Lactu 200 ml oral solution.

Biopharma Ltd. Produces LACTU 100 ML SOLUTION it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.

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