INFLADEX E/D ™
INFLADEX 5 ML EYE DROPS | |
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Generic : | Dexamethasone Sodium phosphate 0.1% |
Thearapeutic : | Ophthalmic |
Pack Size : | 5 ml |
Strength : | |
Dosage Form : | Eye Drop |
Infladex
Dexamethasone Sodium Phosphate 0.1%
Sterile and Pyrogen free Eye/Ear Drops
Composition
- Each ml contains Dexamethasone Sodium Phosphate BP 1 mg,
- Preservative: Benzalkonium Chloride BP 0.1 mg
Description
- It is a sterile and pyrogen-free ophthalmic preparation containing Dexamethasone - a cortisone derivative for topical administration to the eyes.
Clinical Pharmacology
- Dexamethasone is a cortisone derivative whose high activity is due to the presence of a methyl group in the 16-alpha position and of a fluorine atom in the 9-alpha position. The result is that its anti-inflammatory activity is 30 times greater and its overall therapeutic effectiveness is 8-10 times greater than that of hydrocortisone. Like other glucocorticoids, it is anti-allergic, anti-exudative and anti-proliferative.
- Therapeutic concentrations of Dexamethasone are found in both the cornea and aqueous humor 15-30 minutes after local application of a single drop of 0.1% solution. These concentrations persist for 4-6 hours.
- The action of Dexamethasone is to inhibit the phospholipase A2, the first step in prostaglandin synthesis. Also, Dexamethasone inhibits the chemotactic infiltration of neutrophils into the site of inflammation.
Indications and Uses
It is indicated for the treatment of
- Allergic non-infectious blepharitis and conjunctivitis
- Non-infectious keratitis, punctate keratitis, disciform keratitis (provided the corneal surface is intact)
- Inflammation of the anterior uvea (iritis, iridocyclitis )
- Scleritis, episcleritis and myositis
- Post-operative management of cataracts, strabismus & other ocular surgeries
Dosage and Administration
- Instill 1 drop into the conjunctival sac 3-5 times per day. Acute cases: up to 1 drop every hour if necessary.
Contraindications
- Injuries and ulcerating processes of the cornea, particularly those of bacterial or viral origin (herpes simplex, vaccinia), purulent infections of the conjunctiva and eyelids, tuberculosis, mycosis, and glaucoma.
Precautions
- Corticosteroids may mask, activate, or aggravate an infection of the eye. If no improvement is seen after a few days of application, other forms of treatment should be used. Do not touch the dropper tip to any surface as this may contaminate the solution.
Side-Effects
- In predisposed patients, the application of corticosteroids for a period of several weeks may cause a reversible rise in intraocular pressure. Pressure measurements at regular intervals are therefore essential.
Use in Pregnancy & Lactation
- Animal experiments with dexamethasone have shown adverse effects on the fetus. However, no control human studies are available. Dexamethasone ophthalmic preparation should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Drug Interactions
- Specific drug interaction studies have not been conducted with Dexamethasone.
Overdosage
- Overdose through local or accidental oral administration is not likely.
Pharmaceutical Precautions
- Store at room temperature & protect from light. It is desirable that the contents should not be used more than one month after the first opening of the bottle.
Commercial Pack
- Plastic dropper bottle of 5 ml.
Biopharma Ltd. Produces INFLADEX 5 ML EYE DROPS it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.