GOUTEX ™
GOUTEX 100 MG TABLET | |
---|---|
Generic : | Allopurinol |
Thearapeutic : | Antigout |
Pack Size : | 100s |
Strength : | |
Dosage Form : | Tablet |
Goutex
Allopurinol 100 mg Tablet
Composition
- Each tablet contains Allopurinol BP 100 mg.
Pharmacology
Goutex (Allopurinol) is a xanthine oxidase inhibitor that is administered orally. It acts on purine catabolism without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation. Allopurinol is a structural analog of the natural purine base, hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and xanthine to uric acid, the end product of purine metabolism. Goutex is approximately 90% absorbed from the GI tract. Peak plasma levels generally occur at 1.5 hours to 4.5 hours. It has a plasma half-life of about 1 to 2 hours. Approximately 20% of the ingested Goutex is excreted in the feces.
Indication
- Goutex is indicated in the management of patients with signs and symptoms of primary and secondary gout, leukemia, lymphoma, and malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels, recurrent calcium oxalate calculi whose daily uric acid excretion exceeds 800 mg/day in male and 750 mg/day in female patients.
Dosage And Administration
Adults: Mild gout: 200 to 300 mg/day. Moderately severe tophaceous gout: 400 to 600 mg/day. The minimal effective dosage is 100 to 200 mg daily and the maximal recommended dosage is 800 mg daily. To reduce the possibility of flare-ups of acute gouty attacks, it is recommended that the patient start with a low dose of Goutex (100 mg daily) and increase at weekly intervals by 100 mg until a serum uric acid level of 6 mg/day or less is attained but without exceeding the maximal recommended dosage.
Recurrent calcium oxalate stones: 200 to 300 mg/day.
Children:
- Age 6-10 years: In secondary hyperuricemia associated with malignancies may be given 300 mg Goutex daily.
- Age under 6 years: generally given 150 mg daily.
- Contraindication And Precaution
- Patients who have developed a severe reaction to Allopurinol should not restart the drug. Allopurinol should be withdrawn immediately when a skin rash or other evidence of sensitivity occurs. Dosage reduction should be considered in the presence of severe hepatic or renal disorder.
Side Effects
- The most frequent adverse reaction to allopurinol is skin rash such as pruritic maculopapular skin eruptions, sometimes scaly or exfoliative. Some patients with the most severe reaction, also had fever, chill, arthralgias, cholestatic jaundice, eosinophilia, and mild leukocytosis or leukopenia.
Drug Interaction
- Anticoagulant - Allopurinol prolongs the half life of the anticoagulant, dicumarol. Diuretic - Concomitant use of Allopurinol and thiazide diuretics may contribute to the enhancement of Allopurinol toxicity. Cytotoxic agent - Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic disease.
Use in pregnancy & lactation
- There are, however, no adequate or well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly indicated. Allopurinol has been found in breast milk, caution should be exercised when Allopurinol is administered to a lactating mother.
Storage Condition
- Store below 30ºC in a dry place. Keep away from light.
Warning
- To be used as directed by the physician. Keep out of reach of children.
Presentation
- Each Box contains 10 x 10 tablets in the alu-pvc blister pack.
Biopharma Ltd. Produces GOUTEX 100 MG TABLET it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.