GLUCORID ™

GLUCORID 1 MG TABLET
Generic : Glimepiride
Thearapeutic : Antidiabetic
Pack Size : 30s
Strength :
Dosage Form : Tablet

Glucorid

Glimepiride

COMPOSITION

  • Glucorid 1 mg Tablet: Each tablet contains Glimepiride USP 1 mg.
  • Glucorid 2 mg Tablet: Each tablet contains Glimepiride USP 2 mg.

DESCRIPTION    

The primary mechanism of action of Glimepiride is the lowering of blood glucose by stimulating the release of insulin from functioning beta cells. In addition, extrapancreatic effects may also play a vital role in the activity of Glimepiride. Administration of Glimepiride can lead to increased sensitivity of peripheral tissues to insulin. After oral administration, Glimepiride is completely (100%) absorbed from GIT. Glimepiride is completely metabolized by oxidative biotransformation after oral dose.

INDICATIONS

Glucorid is indicated as an adjunct to diet and exercise to lower blood glucose in patients with non-insulin-dependent diabetes mellitus whose hyperglycemia can not be controlled by diet and exercise alone. Glucorid is also indicated for use in combination with insulin to lower blood glucose in patients whose hyperglycemia cannot be controlled by diet and exercise or in conjunction with an oral hyperglycemic agent.

DOSAGE AND ADMINISTRATION

  • Initial dose: 1-2 mg once daily, given with breakfast or the first main meal. Patients sensitive to hypoglycemic drugs should begin at 1 mg once daily. The maximum starting dose is 2 mg.

MAINTENANCE DOSE

  • 1-4 mg once daily. The maximum recommended dose is 8 mg once daily. After a dose of 2 mg is reached, increase the dose at increments of 2 mg at 1-2 week intervals based on the patient's blood glucose response. Monitor long-term efficacy by measurements of HbA1c levels, for example, every 3-6 months.

COMBINATION INSULIN THERAPY

The recommended dose is 8 mg once daily with the first main meal with low-dose insulin patients on other oral antidiabetic agents. When transferring patients to Glimepiride, no transition period is necessary. No exact dosage relationship exists between Glimepiride and the other oral hypoglycemic agents. Observe patients carefully when being transferred from longer half-life sulfonylureas to Glimepiride due to potential overlapping of drug effects.

CONTRAINDICATIONS

  • Glimepiride is not suitable for the treatment of Type-2 diabetes ( e.g. for the treatment of diabetes with a history of ketoacidosis), or of diabetic precoma or coma. Glimepiride must not be used for patients ' hypersensitivity to Glimepiride, other sulfonylureas & other sulfonamides.

PRECAUTIONS

In the initial weeks of treatment, the risk of hypoglycemia may be increased and necessitates careful monitoring. If such risk is present it may be necessary to adjust the dosage of Glimepiride. Hypoglycemia can almost always be promptly controlled by immediate intake of carbohydrates (glucose or sugar, e.g. in the form of sugar lumps, sugar-sweetened fruit juice, or sugar-sweetened tea).

SIDE-EFFECTS

  • Hypoglycemia, temporary visual impairment, nausea, vomiting, diarrhea, abdominal pain, urticaria, and fall in blood pressure.

DRUG INTERACTIONS

Potentiation of the blood-sugar-lowering effect may occur with insulin and other oral anti-diabetics, ACE inhibitors, allopurinol, anabolic steroids and male sex hormones, chloramphenicol, coumarin derivatives, fluoxetine, MAOIs, miconazole, para-aminosalicylic acid, pentoxifylline (high dose parenteral), phenylbutazone, oxyphenbutazone, quinolones, salicylates, sulfonamides, tetracyclines & beta blockers. Weakening of the blood sugar lowering effect may occur with acetazolamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine and other sympathomimetic agents, laxatives, estrogens and progesterones, phenothiazines, phenytoin, rifampicin, thyroid hormones. H2 –receptor antagonists, clonidine, and reserpine may lead to either potentiation or weakening of the blood sugar lowering effect. Both acute and chronic alcohol intakes may potentiate or weaken the blood sugar-lowering action of Glimepiride unpredictably.

USE IN PREGNANCY AND LACTATION

  • Pregnancy: Glimepiride must not be taken during pregnancy; a changeover to insulin is necessary. Patients planning a pregnancy must inform their physician, and should changeover to insulin.
  • Nursing mothers: Ingestion of Glimepiride with breast milk may harm the child. Therefore, breast-feeding women must not take Glimepiride. Either a changeover or a complete discontinuation of breastfeeding is necessary.

COMMERCIAL PACK

  • Glucorid 1 mg Tablet: Each box contains 3×10 tablets in a blister pack.
  • Glucorid 2 mg Tablet: Each box contains 3×10 tablets in a blister pack.

Biopharma Ltd. Produces GLUCORID 1 MG TABLET it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.

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