GEFCIN

Gemifloxacin

COMPOSITION

• GEFCIN 320 mg Tablet: Each film-coated tablet contains Gemifloxacin 320 mg as Gemifloxacin Mesylate INN.

PHARMACOLOGY

• Gemifloxacin is a fluoroquinolone antibiotic. It is bactericidal with minimum bactericidal concentrations. Gemifloxacin acts by inhibiting DNA synthesis through inhibition of the bacterial type II topoisomerases, DNA gyrase, and/or topoisomerase IV (TOPO IV) which are both essential for bacterial growth.
• Gemifloxacin is rapidly absorbed after oral administration. It is widely distributed
• throughout the body. Studies in healthy subjects showed that Gemifloxacin is
• distributed rapidly into target tissues and body aids such as the lung (epithelial languid, alveolar macrophages, bronchial tissue) and nasal secretions.
• Following oral administration of Gemifloxacin, approximately 36% and 61% of the dose is excreted in the urine and feces, respectively, as unchanged drugs and metabolites. AUC values were generally only slightly higher (approx. 10%) in women than in men. No dose adjustment is required based on gender

INDICATIONS

• Gemifloxacin is indicated for the treatment of the following bacterial infections in adults caused by sensitive organisms as follows-
• Acute bacterial exacerbation of chronic bronchitis- caused by Streptococcus
• pneumoniae, Haemophilus inuenzae, Haemophilus parainuenzae, or Moraxella catarrhalis.
• Community-acquired pneumonia (of mild to moderate severity)- caused by
• Streptococcus pneumoniae (including multi-drug resistant strains [MDRSP])*, Haemophilus inuenzae, Moraxella catarrhalis, Mycoplasma pneumonia, Chlamydia pneumonia, or Klebsiella pneumonia.

DOSAGE AND ADMINISTRATION

• GEFCIN can be taken with or without food and should be swallowed with a liberal amount of liquid. The recommended dose of GEFCINTM is 320 mg daily, according to the following table:

Biopharma Ltd. Produces GEFCIN 320 MG TABLET it is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.