AMBROXOL ™

AMBROXOL 100 ML SYRUP
Generic : Ambroxol Hydrochloride
Thearapeutic : Expectorant
Pack Size : 100 ml
Strength :
Dosage Form : Syrup

Ambroxol

Ambroxol Hydrochloride

Presentation:

  • Ambroxol Syrup: Each 5 ml syrup contains Ambroxol hydrochloride BP 15 mg.
  • Ambroxol-75 SR Capsule: Each capsule contains sustained-release pellets of Ambroxol hydrochloride equivalent to Ambroxol hydrochloride BP 75 mg.
  • Ambroxol PD: Each 5 ml syrup contains Ambroxol hydrochloride BP 6 mg.

Pharmacology:

Ambroxol is the active metabolite of bromhexine and it has been proven that this metabolite possesses a greater bronchosecretolytic effect than bromhexine. It improves sputum rheology by hydrating mechanism leading to liquefaction of mucus in the lumen of the respiratory tract, thus facilitating expectoration of mucus and reducing dyspnea. It stimulates the production of phospholipids of surfactant by alveolar cells, thus contributing to the lowering of superficial tension in the alveoli. It also reduces bronchial hyperactivity. Ambroxol has anti-inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD, it traditionally improves airway pathways.

Indications:

Productive cough, Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis Inflammatory disease of rhinopharyngeal tract (laryngitis, Pharyngitis, sinusitis, and rhinitis) associated with viscid mucus, Asthmatic bronchitis, bronchial asthma with thick expectoration, Bronchiectasis, Chronic pneumonia.

Dosage and administration:

  • Average daily dose (preferably after meal).

Ambroxol Paediatric Drops:

  • 0 - 6 months old: 0.5 ml, 2 times a day
  • 6 - 12 months old: 1 ml, 2 times a day
  • 1 - 2 years old: 1.25 ml, 2 times a day

Ambroxol Syrup:

  • 2 -5 years old: 2.5 ml (1/2 teaspoonful), 2-3 times a day.
  • 5 - 10 years old: 5 ml (1 teaspoonful), 2-3 times a day.
  • 10 years old and adults: 10 ml (2 teaspoonfuls), 3 times a day.

Ambroxol-75 SR Capsule:

Adults and children over 12 years old: 1 capsule, once daily.

Side-Effects:

Gastrointestinal side effects like epigastric pain, and stomach overfill feeling may occur occasionally. Rarely allergic responses such as eruption, urticaria, or angioneurotic edema have been reported.

Contra-Indications:

Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.

Precautions:

Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.

Drug Interaction:

Ambroxol should not be taken simultaneously with antitussives (e.g. Codeine) because phlegm, which has been liquefied by Ambroxol might not be expectorated.

Use in Pregnancy and Lactation:

Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use it in pregnancy, especially during the first trimester. Safety during lactation has not been established yet.

Storage Condition:

  • Protect from direct light exposure.
  • Store in a cool and dry place, at a temperature not exceeding 30oc.
  • Keep out of the reach of children.

Commercial Pack:

  • Ambroxol  Syrup: A glass bottle contains 100 ml syrup and a measuring cup.
  • Ambroxol-75 SR Capsule: Each box contains 3 x 10 capsules in a blister pack.
  • Ambroxol  PD: Glass bottle contains 15 ml pediatric drop & a dropper.

Biopharma Ltd. produces AMBROXOL 100 ML SYRUP, a suspension syrup containing Paracetamol. This 100 mL bottle offers pain relief and is available for purchase. It is a trusted product for alleviating various discomforts, and it's commonly found in pharmacies and stores.
 

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